List of differentially expressed genes

Metformin example: [Load example]

Organism

Select organism (Currently only Homo sapiens is supported)


Tool description

This tool is aimed at identifying similar experiments based on gene expression profiles characterizing specific phenotypes. The introduced data is compared against the gene expression profiles included in NutriGenomeDB database. Results are presented as a datatable informing about matched nutrigenomics experiments, the number of overlapping genes between the introduced query and experiments hosted in the database, and information about whether those matched genes are mostly over/under expressed. A complete guide can be found at Help page for results interpretation. Finally, the integrated analysis module allows to perform a molecular function enrichment among genes representing the intersection between the phenotypic query and the nutrigenomics experiments hosted in NutrigenomeDB.

Data input

Formatted lines with two values: Gene Symbol and Log2 Fold Change expression values. Both values must be tab separated, commonly copy-pasting from an Excel file with differential gene expression results. For numeric data, the decimal separator must be a dot (.). We recommend a minimum of 500 lines of input in order to get meaningful results. Click on Load example (Text box bottom) to automatically load an example query as data input


If you find NutriGenomeDB useful please cite us:
Data mining of nutrigenomics experiments: Identification of a cancer protective gene signature . Martín-Hernández R., Reglero G., Dávalos A. The Journal of Functional Foods 2019, 42, 380-386.
NutriGenomeDB: a nutrigenomics exploratory and analytical platform . Martín-Hernández R., Reglero G., Ordovás J.M., Dávalos A. Database 2019, Volume 2019.

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